Epilepsy | epilepsy | RNA-dependent RNA polymerase | pyridoxine | Epilepsy Foundation | Voltage-dependent calcium channel | Spike-timing-dependent plasticity | Photosensitive epilepsy | Limited dependent variable | Light-dependent reactions | Epilepsy Phenome/Genome Project | Epilepsy Ireland | Epilepsy Action | Dependent territory | dependent (record label) | ''dependent'' or ''response'' variable | dependent | Cyclin-dependent kinase | Co-Dependent's Day | co-dependent | ATP-dependent Clp protease proteolytic subunit | antibody-dependent cell-mediated cytotoxicity |
Peripheral neuropathy and CNS effects are associated with the use of isoniazid and are due to pyridoxine (vitamin B6) depletion, but are uncommon at doses of 5 mg/kg.
Examples include the use of high doses of pyridoxine (vitamin B6) in some patients with homocystinuria to boost the activity of the residual cystathione synthase enzyme, administration of biotin to restore activity of several enzymes affected by deficiency of biotinidase, treatment with NTBC in Tyrosinemia to inhibit the production of succinylacetone which causes liver toxicity, and the use of sodium benzoate to decrease ammonia build-up in urea cycle disorders.
It is also essential for patients with extremely rare pyridoxine-dependent epilepsy, thought to be caused by mutations in the ALDH7A1 gene.