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The river is formed by the confluence of various streams to the west of Druogno (which marks the watershed between the western and eastern sections of the Val Vigezzo), and runs westward through the narrow valley which connects the high plain of the central Val Vigezza to the Val d’Ossola.
This follows the valley of the Travers River, ascends over the sub-alpine Travers Saddle, the watershed, and then descends the Sabine River valley and gorge to Lake Rotoroa.
The water divide further runs eastwards through the Northern Limestone Alps, ending at "Vienna Gate", the steep slopes of the Leopoldsberg (425 m) high above the Danube River.