X-Nico

unusual facts about Adaptor protein



BPS domain

In molecular biology, the BPS domain (Between PH and SH2) domain is a protein domain of approximately 45 amino acids found in the adaptor proteins Grb7Grb10/Grb14.

Rap1

RIAM (Rap1–GTP-interacting adapter molecule) is a broadly expressed adapter protein that contains an RA (Ras association)-like domain, a PH domain, and several proline-rich sequences.


see also

GAB2

The interaction between GAB2 and Grb2 at the cell membrane recruits another adaptor protein, the Src homology domain-containing transforming protein 1 (SHC1), before being able to recruit SH2 domain containing molecules.

Interferon gamma

IFNγ suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, which otherwise stimulates the production of NF-κB.

Synaptic pruning

Ensuing binding of Ephrin-B3 to the cytoplasmic adaptor protein, Grb4, leads to the recruitment and binding of Dock180 and p21 activated kinases (PAK).

Tirap

TIRAP, toll-interleukin 1 receptor domain containing adaptor protein