NMDA receptors are particularly important when they become overactive during withdrawal from alcohol as this causes symptoms such as agitation and, sometimes, epileptiform seizures.
The name RTX (repeats in toxin) refers to the glycine and aspartate-rich repeats located at the C-terminus of the toxin proteins, which facilitate export by a dedicated T1SS encoded within the rtx operon.
Lysergic acid diethylamide | fatty acid | acid | Lords of Acid | Velvet Acid Christ | sulfuric acid | The Acid House | salicylic acid | Rosmarinic acid | Fatty acid | Vic Acid | The Electric Kool-Aid Acid Test | The Acid House (film) | tannic acid | Sulfonic acid | Stringfellow Acid Pits | Red fuming nitric acid | Omega-3 fatty acid | Nucleic acid sequence | Mosher's acid | lysergic acid diethylamide | humic acid | gallic acid | Ethylenediaminetetraacetic acid | Dipicolinic acid | Acid Western | Acid Rap | Acid | 5-Hydroxyindoleacetic acid | 4-Aminobenzoic acid |
Finally, DNMT2 (TRDMT1) has been identified as a DNA methyltransferase homolog, containing all 10 sequence motifs common to all DNA methyltransferases; however, DNMT2 (TRDMT1) does not methylate DNA but instead methylates cytosine-38 in the anticodon loop of aspartic acid transfer RNA.
Starting with aspartic acid β esters undergoing acylation to differentiate the first substituent, linked to carbon-2, followed by Dakin-West conversion to keto-amide to introduce the second substituent, and ending with the Robinson-Gabriel cyclodehydration at 90°C for 30 minutes with either phosphorus oxychloride in DMF or catalytic sulfuric acid in acetic anhydride.
Achatin-I (glycyl-phenylalanyl-alanyl-aspartic acid) is a neuroexcitatory tetrapeptide from giant African snail (Achatina fulica).