X-Nico

unusual facts about Azinphos-methyl


Azinphos-methyl

Azinphos-methyl (Guthion) (also spelled azinophos-methyl) is a broad spectrum organophosphate insecticide manufactured by Bayer CropScience, Gowan Co., and Makhteshim Agan.


Asymmetric induction

In the original 1952 publication, additional evidence was obtained for the structural assignment of the reaction products by applying them to a Chugaev elimination, wherein the threo isomer reacts to the cis isomer of -α-methyl-stilbene and the erythro isomer to the trans version.

Bardoxolone methyl

Bardoxolone methyl was previously being investigated by Reata Pharmaceuticals, Inc. in partnership with Abbott Laboratories and Kyowa Hakko Kirin, as an experimental therapy for advanced chronic kidney disease (CKD) in type 2 diabetes mellitus patients.

Calostoma cinnabarinum

The methyl ester of calostomal was subjected to NMR spectroscopy and was identified as all-trans-16-oxohexadeca-2,4,6,8,10,12,14-heptaenoic acid.

ChIP-on-chip

Also available are antibodies against a specific histone modification like H3 tri methyl K4.

Chugai Pharmaceutical Co.

Scientists at Chugai discovered an erythromycin-derived motilin agonist called Mitemcinal (aka GM-611 or 3'-N-dimethyl-11-deoxy-3'-N-isopropyl-12-O-methyl-11-oxo-8,9-didehydroerythromycin.) Mitemcinal was believed to have strong prokinetic properties, similar to its parent molecule, but lack antibiotic properties.

Copper extraction techniques

The treated ore is introduced to a water-filled aeration tank containing surfactant such as methylisobutyl carbinol (MIBC).

CTBP2

For example, histone deacetylase 1 (HDAC1) and HDAC2 can remove the activating mark histone 3 acetyl lysine 9 (H3K9Ac), then the histone methylase G9a can add methyl groups, while the histone demethylase lysine specific demethylase 1 (LSD1) can remove the activating mark H3K4me.

Discovery and development of triptans

Side chains of the surrounding amino acids can have an effect on the binding of the nitrogen atom, mainly three Phe can affect the methyl groups bound to the nitrogen atom (not shown in figure 2).

DMT1

DMT1 expression is found to be increased in the substantia nigra of Parkinson's patients and in the ventral mesencephalon of animal models intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) - a neurotoxin widely used experimentally to produce Parkinsonian symptoms.

Environmental disaster

Bhopal disaster, 1984 - Release of methyl isocyanate gas and other chemicals Some estimate 8,000 people died within two weeks.

F430

Cofactor F430, F430, the prosthetic group of the enzyme methyl coenzyme M reductase

Geissoschizine methyl ether

Geissoschizine methyl ether is an alkalod contained in the kampo medicine Yokukansan.

Hagemann's ester

Hagemann's ester, or ethyl-2-methyl-4-oxo-2-cyclohexenecarboxylate, is an organic compound that was first prepared and described in 1893 by German chemist Carl Hagemann.

Hydrate

Methanol is often sold as “methyl hydrate”, implying the incorrect formula CH3OH2, while the correct formula is CH3–OH.

Lysergic acid hydroxyethylamide

D-Lysergic acid α-hydroxyethylamide (LSH, LAH), also known as D-lysergic acid methyl carbinolamide, is an alkaloid of the ergoline family, and occurs in various species in the Convolvulaceae (morning glory) family and some species of fungi.

MBD3

Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD).

MDEA

Methyl diethanolamine (N-methyl-diethanolamine), CH3N (C2H4OH)2, a chemical used for amine gas treating, also known as gas sweetening or acid gas removal, the removal of hydrogen sulphide and carbon dioxide from gases in the petrochemical industry

MECP2

Human proteins MECP2 (this protein), MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD).

MENT

Trestolone (7α-methyl-19-nortestosterone) a synthetic androgen developed for male contraception

Methyl salicylate

The compound methyl salicylate was first isolated (from the plant Gaultheria procumbens) in 1843 by the French chemist Auguste André Thomas Cahours (1813-1891), who identified it as an ester of salicylic acid and methanol.

Methyl-CpG-binding domain

The MBD of MeCP2, MBD1, MBD2, MBD4 and BAZ2 mediates binding to DNA, and in cases of MeCP2, MBD1 and MBD2, preferentially to methylated CpG.

Mi-2/NuRD complex

The NuRD complex contains seven subunits: the histone deacetylase core proteins HDAC1 and HDAC2, the histone-binding proteins RbAp46 and RbAp48, the metastasis-associated proteins MTA1 (or MTA2 / MTA3), the methyl-CpG-binding domain protein MBD3 (or MBD2) and the chromodomain-helicase-DNA-binding protein CHD3 (aka Mi-2alpha) or CHD4 (aka Mi-2beta).

MTSL

MTSL (S-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl methanesulfonothioate) is a chemical compound which can be used as a nitroxide (amine oxide) paramagnetic spin label in protein Electron paramagnetic resonance spectroscopy experiments.

N-Methyl-D-aspartic acid

NMDA receptors are particularly important when they become overactive during withdrawal from alcohol as this causes symptoms such as agitation and, sometimes, epileptiform seizures.

Orthoester

Another example is the bicyclic OBO protecting group (4-methyl-2,6,7-trioxa-bicyclo2.2.2octan-1-yl) which is formed by the action of (3-methyloxetan-3-yl)methanol on activated carboxylic acids in the presence of Lewis acids and was developed by Elias James Corey.

Petunidin

Petunidin could form in the exocarp of fruits from delphinidin, with an anthocyanin flavonoid O-methyltransferase (Catechol-O-methyl transferase) catalyzing the B-ring methylation and S-Adenosyl-L-methyl-3H methionine being the methyl group donor.

Pirimiphos-methyl

This is one of several compounds used for vector control of Triatoma.

These insects are implicated in the transmission of Chagas disease in the Americas.

S-Adenosyl methionine

Methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.

Tetrapeptide

Tentoxin (cyclo(N-methyl-L-alanyl-L-leucyl-N-methyl-trans-dehydrophenyl-alanyl-glycyl)) is a natural cyclic tetrapeptide produced by phytopathogenic fungi from genus Alternaria.

Thebaine

Thebaine (paramorphine), also known as codeine methyl enol ether, is an opiate alkaloid, its name coming from the Greek Θῆβαι, Thēbai, an ancient city in Upper Egypt.

Varespladib methyl

Varespladib methyl (also known as A-002, formerly LY333013 and S-3013) is a secretory phospholipase A2 (sPLA2) inhibitor formerly under development by Anthera Pharmaceuticals as a treatment for acute coronary syndrome (ACS).

Voacangine

Voacangine (12-methoxyibogamine-18-carboxylic acid methyl ester) is an alkaloid found predominantly in the rootbark of the Voacanga africana tree, as well as in other plants such as Tabernanthe iboga, Tabernaemontana africana, Trachelospermum jasminoides and Ervatamia yunnanensis.


see also