Patients with B cell deficiencies are highly susceptible to encapsulated bacterial infections.
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Tabalumab (LY 2127399) is an anti-B-cell activating factor (BAFF) human monoclonal antibody designed for the treatment of autoimmune diseases and B cell malignancies.
A third member of this family - RHBDD1 - cleaves Bcl-2-interacting killer (BIK) - a proapoptotic member of the B cell lymphoma 2 (Bcl-2) family.
Notably, MYC was found to directly control BYSL, a highly conserved, but poorly characterized gene, and is the largest hub in the whole B cell network.
JY cell line, Epstein-Barr virus (EBV)-immortalised b cell lymphoblastoid line
Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20.
B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population.