It is found in a wide variety of plant and psychoactive toad species and, like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen by South American shamans for thousands of years.
Reported side effects include anxiety, restlessness, muscle tension, jaw tightness, pupil dilation, tachycardia, headaches, nausea, and vomiting, among other effects that might commonly be attributed to LSD, psilocybin, DMT and MDMA, such as delusions and hallucinations.
Peganum Harmala contains Harmaline, which is a strong MAO-inhibitor, and it is therefore often used as a 1st component in Ayahuasca ceremonies in order to inhibit the metabolisation of an orally-administered DMT molecule (2nd component).
Fitzgerald and Siournis reported in the Australian Journal of Chemistry (1965, volume 18, pp. 433–4) that a sample of the bark contained 0.36% of the hallucinogen DMT as well as 0.24% of N-methyltryptamine.
Authors used music videos by Generacija bez budućnosti, Obojeni Program, Ritam nereda, Atheist Rap, Zbogom Brus Li, Vrisak generacije, Boye, Love Hunters, DMT and Ska ringišpil.
DMT's scheduler handles 4 configurable scheduling frequencies: Regular Interval, Daily, Weekly and Monthly (e.g. 1st Monday of each month, last day of each month, every 10th of the month, etc.).
Root bark of D. illinoensis has been found to contain N,N-DMT, NMT, N-hydroxy-N-methyltryptamine, 2-hydroxy-N-methyltryptamine, and gramine (toxic).
In this view, if MAOI is neither present in the plant nor added to the mixture, the enzyme MAO will break apart DMT in the human gut, preventing the active molecule from entering blood and brain.
Furthermore, the pineal gland is a hypothetical candidate for producing a mind's eye; Rick Strassman and others have postulated that during near death experiences (NDE's) and dreaming, the gland might secrete a hallucinogenic chemical 'N,N-Dimethyltryptamine' (DMT) to produce internal visuals when external sensory data is occluded.
Classical or serotonergic psychedelics (agonists for the LSD (also known as "acid"), psilocin (the active constituent of psilocybin mushrooms, commonly known as "magic mushrooms" or "shrooms"), mescaline (the active constituent of peyote), and DMT (the active constituent of ayahuasca and potentially an endogenous psychedelic compound).
In the U.S., he worked with Julius Axelrod and others on the metabolism of DMT and related compounds in healthy and schizophrenic volunteers.