After a term as commander in Milan, Coloma returned to London in 1630 to restore peace between the two crowns.
The next year though, he was decisively beaten by superior forces in the Battle of Piacenza, after which he had to abandon the Duchy of Milan.
Under the rule of the Duchy of Milan as well as the Swiss Confederation, the village was an independent municipality with its own statutes and rights.
A first setback came with the Battle of Arbedo in 1422, where the Swiss were defeated by the Duchy of Milan, and in a treaty of 1426, the border of the duchy was moved back to the Gotthard Pass.
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Besieging Domodossola and marauding the valleys, the Swiss were decisively defeated by the Ducal Milanese at the Battle of Crevola in April 1487.
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When the Visconti family died out in the 15th century, the emblem retained its association with the Duchy of Milan and became part of the coats of arms of the House of Sforza; the presence of Biscione in Poland (Sanok) and Belarus (Pruzhany) is due to queen Bona Sforza.
In the same year he was enfeoffed with large estates in the Duchy of Milan (County of Vespolate 1524–1530, County of Gallarate 1530).
From 1635, Piedmont had been forced to join France in its war against Spain, fighting principally against Spanish-controlled former Duchy of Milan, though its ruler, Victor Amadeus I, Duke of Savoy, avoided formally declaring war on Spain.
The name stems from the historical division of the area that it marked, between the State of Milan, the Republic of Venice and the Grisons canton of Switzerland.
These qualities made the Castellanza a strategic base for the House of Visconti and the House of Sforza of the Duchy of Milan until the Battle of Novara (1513).
"Insubria" thus denoted the core of the then extensive Duchy of Milan, as attested in the writings of Benzo d'Alessandria, Giovanni Simonetta, Thomas Coryat, Bernardino Corio and Andrea Alciato.
If the King Louis XII were to die without producing a male heir, Charles of the House of Habsburg would receive as dowry the Duchy of Milan, Genoa and its dependencies, the Duchy of Brittany, the counties of Asti and Blois, the Duchy of Burgundy, the Viceroyalty of Auxonne, Auxerrois, Mâconnais and Bar-sur-Seine.