He visited Germany between 1833 and 1835, spending the year of 1833 in Professor Friedrich Wöhler's private laboratory in Hesse-Cassel, and then spending nine months in the laboratory of Professor Gustav Magnus in Berlin.
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In the application for this position he was supported by such famous chemists as Baeyer, Beilstein, Bunsen, Butlerov, Erlenmeyer, Hofmann, Kolbe, Volhard and Wöhler.
He finished in 1862 and began studying chemistry in Göttingen in Wöhler's laboratory, then supervised by Friedrich Konrad Beilstein and Rudolph Fittig.
The first demonstration of organic total synthesis was Friedrich Wöhler's synthesis of urea in 1828, which demonstrated that organic molecules can be produced from inorganic precursors, and the first commercialized total synthesis was Gustaf Komppa's synthesis and industrial production of camphor in 1903.