There are two types of excitatory inputs received by GABAergic granule cells; those activated by an AMPA receptor and those activated by a NMDA receptor.
Her research has examined the composition of NMDA receptors and their expression patterns in brain cell populations.
In a largescale phospho screening of the PSD, it was found to be phosphorylated following activation of the NMDAR complex.
Assuming the two are closer than the last trial, this “critic” then sends a signal activating NMDA receptors on the articulator of the song.
receptor | LDL receptor | Receptor (biochemistry) | Continuous erythropoietin receptor activator | GABA receptor | Epidermal growth factor receptor | NMDA receptor | Sensory receptor | receptor (biochemistry) | metabotropic glutamate receptor | 5-HT2A receptor | VLDL receptor | TGF beta receptor 2 | receptor antagonist | epidermal growth factor receptor | 5-HT receptor | RAR-related orphan receptor alpha | Metabotropic glutamate receptor 5 | Metabotropic glutamate receptor 2 | G protein-coupled receptor | AMPA receptor | Adenosine A1 receptor | Toll-like receptor | TNF receptor associated periodic syndrome | taste receptor | Sigma-1 receptor | Receptor antagonist | Receptor activity-modifying protein | Pancreatic polypeptide receptor 1 | Nuclear receptor |
Thus NMDA receptor antagonists including MK-801 have been extensively studied for use in treatment of diseases with excitotoxic components, such as stroke, traumatic brain injury, and neurodegenerative diseases such as Huntington's, Alzheimer's, and amyotrophic lateral sclerosis.