It consists of two copies of each of the four core histone proteins (H2A, H2B, H3 and H4).
histone H3 | Histone H3 | Histone H2B | Histone H2A | Histone H4 | Histone deacetylase |
The aberrant epigenetic landscape of the cancer cell is characterized by a global genomic hypomethylation, CpG island promoter hypermethylation of tumor suppressor genes, an altered histone code for critical genes and a global loss of monoacetylated and trimethylated histone H4.