X-Nico

unusual facts about Homology



Betatrophin

Since betatrophin is a member of the angiopoietin-like gene family and shares extensive homology with Angptl4 and Angptl3, the name Angptl8 is preferred.

CAPD

CAPD library - C++ library for rigorous numerics in dynamical systems and homology computation.

Evolution of sexual reproduction

For example, recA recombinase, that catalyses the key functions of DNA homology search and strand exchange in the bacterial sexual process of transformation, has orthologs in eukaryotes that perform similar functions in meiotic recombination (see Wikipedia articles RecA, RAD51 and DMC1).

History of manifolds and varieties

Henri Poincaré's 1895 paper Analysis Situs studied three-and-higher-dimensional manifolds(which he called "varieties"), giving rigorous definitions of homology, homotopy (which had originally been defined in the context of late nineteenth-century knot theory, developed by Maxwell and others), and Betti numbers and raised a question, today known as the Poincaré conjecture, based his new concept of the fundamental group.

MATH domain

The MATH domain, in molecular biology, is a binding domain that was defined originally by a region of homology between otherwise functionally unrelated domains, the intracellular TRAF-C domains of TRAF proteins and a C-terminal region of extracellular meprins A and B.

MLC1

Furthermore, MLC1 has highest homology with the KCNA1 shaker-related voltage-gated potassium channel (Kv1.1).

MYOM2

Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains.

Normal invariant

This kind of cobordism theory is a homology theory whose coefficients have been calculated by Thom: therefore the cobordism classes of such maps are computable at least in theory for all spaces X.

Of Pandas and People

A review of Of Pandas and People by paleontologist Kevin Padian of the University of California at Berkeley for the National Center for Science Education's Bookwatch Reviews in 1989 called the book a "wholesale distortion of modern biology", and says that FTE's writers had misrepresented such topics as the Cambrian explosion, the history of birds, and the concept of homology.

Phosphatidylinositol 3,4-bisphosphate

PtdIns(3,4)P2 is dephophosphorylated by the phosphatase INPP4B on the 4 position of the inositol ring and by the TPTE (transmembrane phosphatases with tensin homology) family of phosphatases on the 3 position of the inositol ring.

Phylogenetic profiling

Along with examination of conserved synteny, conserved operon structure, or "Rosetta Stone" domain fusions, comparing phylogenetic profiles is a designated a "post-homology" technique, in that the computation essential to method begins after it is determined which proteins are homologous to which.

Relative contact homology

The relative SFT of this pair is a differential graded algebra; Ng derives a powerful knot invariant from a combinatorial version of the zero-th degree part of the homology.

UVR8

It shares sequence homology with mammalian proteins involved in regulating chromatin condensation, for example the human RCC1 gene product.

Victor Bangert

; Klingenberg, W. (1983) Homology generated by iterated closed geodesics.

VIPR2

While the receptors for VIP (VIRP 1 and 2) and PACAP (ADCYAP1R1) share homology, they differ in their substrate specificities and expression patterns.

Voltage sensitive phosphatase

The homologues to Ci-VSP in mammals are called Transmembrane phosphatases with tensin homology, or TPTEs.


see also