A number of alternative markers has been proposed (such as NGAL, KIM-1, IL18 and cystatin C), but none are currently established enough to replace creatinine as a marker of renal function.
The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18.
IL-1α is a unique member in the cytokine family in the sense that the structure of its initially synthesized precursor does not contain a signal peptide fragment (same is known for IL-1β and IL-18).
Components of signalization pathway of IL-1R which are involved in cellular response to IL-1 also mediate responses to other cytokines (IL-18 and IL-33), Toll-like receptors (TLRs), and many forms of cytotoxic stress.
Also, the exact cytokine responsible has yet to be elucidated, with IL-12, IL-18 and IL-13 having been most studied in this regard, yet never conclusively implicated.
Interleukin 3 | Interleukin 6 | Interleukin 5 | Interleukin 18 | Interleukin 17 | Interleukin 4 | Interleukin 15 | Interleukin 8 | Interleukin 32 | Interleukin 24 | Interleukin 2 | Interleukin 12 | interleukin 6 (IL-6) | Interleukin-3 receptor | Interleukin 22 | Interleukin 13 | Interleukin 12 receptor, beta 2 subunit | Interleukin 10 |