X-Nico

3 unusual facts about interleukin 6


Centroblasts

These metabolically active B cells proliferate in the germinal center of a secondary lymphoid follicle following exposure to follicular dendritic cell cytokines, such as IL-6, IL-15, 8D6, and BAFF.

Copper peptide GHK-Cu

Even though an exact mechanism remains unclear, in a recent study GHK and its copper complexes decreased TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts.

Gliosis

Some of the many signalling molecules used in these pathways include the cytokines interleukin 6 (IL-6), ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF).


Influenza A virus subtype H2N3

Blood plasma levels of Interleukin 6 (IL-6), Interleukin 8, monocyte chemotactic protein-1 and Interferon-gamma were significantly increased in swine H2N3 compared to human H2N2 infected animals supporting the previously published notion of increased IL-6 levels being a potential marker for severe influenza infections.

Procalcitonin

PCT has the greatest sensitivity (85%) and specificity (91%) for differentiating patients with systemic inflammatory response syndrome (SIRS) from those with sepsis, when compared with IL-2, IL-6, IL-8, CRP and TNF-alpha.


see also

Tocilizumab

Interleukin 6 and its receptor were discovered and cloned at Osaka University, Japan, by Tadamitsu Kishimoto in the 1980s.