A test tube is prepared with basophile stimulation buffer (BSB) including Interleukin 3 and an allergen which is to be tested.
In EG cytokines IL-3, IL-5 and granulocyte macrophage colony stimulating factor (GM-CSF) may be behind the recruitement and activation.
The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5.
IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells.
IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells (as opposed to myeloid progenitor cells where differentiation is stimulated by IL-3).
In fact, the β-subunit of the IL-5 receptor is also found in IL-3 and GM-CSF receptors where it is associated with IL-3Rα and GM-CSFRα subunits respectively.
The granulopoiesis is regulated by humoral agents, like Colony Stimulating Factor and Interleukin 3.
The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ).
Interleukin 3 | Interleukin 6 | Interleukin 5 | Interleukin 18 | Interleukin 17 | Interleukin 4 | Interleukin 15 | Interleukin 8 | Interleukin 32 | Interleukin 24 | Interleukin 2 | Interleukin 12 | interleukin 6 (IL-6) | Interleukin-3 receptor | Interleukin 22 | Interleukin 13 | Interleukin 12 receptor, beta 2 subunit | Interleukin 10 |