The section in El Paso County is named the Ronald Reagan Highway, and through Pueblo it is named the John F. Kennedy Memorial Highway.
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The drop off from the Plains to the Piedmont is noticeable to motorists driving southward from Cheyenne, Wyoming on Interstate 25.
The airport is near the junction of Interstate 25 (concurrent with U.S. Highway 85 and U.S. Highway 87), Highway 10, Highway 69, and U.S. Highway 160.