I-579 allows Liberty Bridge traffic easy access to I-279, and I-279 southbound traffic easier access to Consol Energy Center, downtown, and eastern regions of the city, while I-279 southbound continues to Heinz Field, PNC Park, and to westbound I-376 which leads to the Pittsburgh International Airport.
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Before reaching Oakland, it passes by Duquesne University and Mercy Hospital along the edge of a cliff several hundred feet above the Monongahela River with spectacular views of the city's South Side neighborhood and includes partial interchanges with Interstate 579 and Interstate 376.