Interstate 75 | Interstate 90 | Interstate 5 | Interstate 94 | Interstate 81 | Interstate 80 | Interstate 70 | Interstate 40 | Interstate 95 | Interstate 10 | Interstate 65 | Interstate 64 | Interstate 44 | Interstate 90 in Minnesota | Interstate 71 | Interstate 35 | Interstate 15 | Interstate 476 | Interstate 78 | Interstate Highway System | Interstate 85 | Interstate 74 | Interstate 294 | Interstate 20 | Interstate Commerce Commission | Interstate 87 | Interstate 55 | Interstate 471 | Interstate 287 | Interstate matches in Australian rules football |
32 law officials were sent to Hattiesburg to assist with traffic control near the intersection with I-59 and U.S. Route 49.
Interstate 459 (abbreviated I-459) is a bypass highway of Interstate 59 that is an alternate Interstate Highway around the southern sides of Birmingham, Bessemer, and several other cities and towns in Jefferson County.
U.S. 49 passes Hattiesburg's primary medical facility, Forrest General Hospital, and the campus of the University of Southern Mississippi before arriving at another, more standard cloverleaf interchange with Interstate 59.