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Although her death was ostensibly due to tuberculosis and a fever more colorful scenarios have been suggested over the years, among them a theory that she was poisoned (this theory was dramatized in the film The Naked Maja).
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Goya executed several well-known portraits of the duchess, most of them during his stay at Sanlúcar de Barrameda (one of the Andalusian country seats of the House of Medina-Sidonia), shortly after the death of her husband, the Duke of Medina-Sidonia, in 1796.