He had married twice, firstly in Constantinople ca 1318 or 1318 to a Kantakouzene (died ca 1330), without issue, and secondly in 1330–1332, Theodora Syrgiannaina (died 1347/1349), sister of the pinkernes ("cupbearer") Syrgiannes Palaiologos Philanthropenos, with whom he fathered two children.
Syrgiannes's ambition, inveterate plotting, and multiple betrayals made him one of the darkest figures of the era in the eyes of both contemporary and later historians: the 14th-century historian Nikephoros Gregoras compared his flight to Serbia with Themistocles's flight to the Persians, while Donald Nicol likened him to Alcibiades and Angeliki Laiou called him "the most evil presence" of the civil war.
Michael VIII Palaiologos | Palaiologos | John V Palaiologos | Andronikos II Palaiologos | Manuel II Palaiologos | Graitzas Palaiologos | Andronikos IV Palaiologos | Theodore I Palaiologos | Syrgiannes Palaiologos | Constantine XI Palaiologos | Andronikos III Palaiologos |