When Graham betrayed her husband to James Douglas, 4th Earl of Morton, she and her baby escaped to the Continent, arriving in Bruges on 31 August 1570, where she sought aid from Pope Pius V and King Philip II of Spain to raise money for her husband's ransom; the Pope gave her four thousand crowns and King Philip sent her six thousands marks.
The Ghislieri College (Ital. Collegio Ghislieri), founded in 1567 by Pope Pius V, is the second most ancient college in Pavia and co-founder of the IUSS, located in Pavia as well.
Following early battles across France, Protestants decided to intentionally antagonize Pope Pius V by establishing a stonghold in Ménerbes, initially with 150 soldiers and followers led by Scipione de Valvoire, Gaspard Pape de Saint-Auban, and a baron from Germany.
St. Pope Pius V (1566 - 1572), who was a Dominican, changed the papal color to white by continuing to wear the white color of his Dominican religious order, and it has remained so since.
An article by Agostino Paravicini Bagliani on L'Osservatore Romano of 31 August 2013 states that the earliest document that speaks explicitly of the Pope wearing white is the Ordo XIII, a book of ceremonies compiled in about 1274 under Pope Gregory X.
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He also immediately commissioned a representative tomb from the sculptor Pierre Le Gros the Younger to be erected in the Sistine Chapel of the Basilica di Santa Maria Maggiore.
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His response to the Queen Elizabeth I of England assuming governance of the Church of England included support of the imprisoned Mary, Queen of Scots, and her supporters in their attempts to take over England "ex turpissima muliebris libidinis servitute" “from the sordid libidinous slavery to women”.
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His sculptural work can be seen in Rome in the grandiose funeral chapel of Pope Pius V designed by Domenico Fontana at the Basilica di Santa Maria Maggiore (Saint Francis), in the Church of the Gesù (one of four marble angels in the third chapel on the right) and in the right transept of the Chiesa Nuova (Saint John the Evangelist and Saint John the Baptist, both signed).
Expelled with other Jews by Pope Pius V, and suffering a loss of 10,000 gold pieces, he went to Pesaro, and thence to Ferrara, where he remained till 1575.
Henri d'Angoulême took a major role in the two extended military battle against Huguenot strongholds during the height of the French Wars of Religion, engaging in the massive Siege of La Rochelle (1572–1573), organized by the Duke of Anjou, future Henry III of France, and leading the five-year Siege of Ménerbes (1573–1578), fought at a citadel in the Luberon foothills cherished by Pope Pius V.
Pope Pius V ordered the construction of a chapel strictly reserved for the Guards behind the bastion of Nicholas V. The construction of the building dates back to 1568 under the direction of architect Nanni di Baccio Bigio.
Baius’ work was condemned by the theological faculties in Salamanca (1565) and Alcalá (1567), and 97 of his theses were thereafter condemned by Pope Pius V in the bull Ex omnibus afflictionibus on 1 October 1567.