He was appointed Bishop of Seleucia in Isauria, between the years 432 and 447, and was one of those who took part in the Synod of Constantinople, which was summoned in 448 by the Patriarch Flavian for the condemnation of the Eutychian errors and the deposition of their great champion, Dioscurus of Alexandria.
After the death of the last Iconoclast emperor, Theophilos, his young son Michael III, with his mother the regent Theodora, and Patriarch Methodios, summoned the Synod of Constantinople in 842 to bring peace to the Church.
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