X-Nico

unusual facts about T cells



Butyrate

It has been shown that Butyrate inhibits activity of HDAC1 that is bound to the Fas gene promoter in T cells, resulting in hyperacetylation of the Fas promoter and up-regulation of Fas receptor on the T cell surface.


see also

Antigen

In order to keep the cytotoxic cells from killing cells just for presenting self-proteins, self-reactive T cells are deleted from the repertoire as a result of tolerance (also known as negative selection).

CD4+ T cells and antitumor immunity

Historically, much more attention and funding has been devoted to the role of CD8+ T cells in antitumor immunity, rather than to CD4+ T cells.

Entry inhibitor

CD4, a protein receptor found on the surface of helper T cells in the human immune system, also called CD4+ T cells

Interleukin 10

IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells.

MAFA

More recently, human and mouse homologues of MAFA have been discovered yet also (or only) expressed by NK and T-cells.

Natural killer T cell

They and other CD1d-restricted T cells ('Type 2' NKT) recognize lipids and glycolipids presented by CD1d molecules, a member of the CD1 family of antigen presenting molecules, rather than peptide-MHC complexes.

Natural Killer T cells can share other features with NK cells as well, such as CD16 and CD56 expression and granzyme production.

Phosphatidylinositol 5-phosphate

In T-cells, two “downstream of tyrosine kinase” proteins DOK1 and DOK2 are proposed as PtdIns5P-binding proteins and effectors.

SRBC

CD2, a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells