Actin filaments along these cytoplasmic strands pull the nucleus into the center of the cell.
Cell surface (cortical) actin remodeling is a cyclic process, and each step is responsive to cell signaling, making this a dynamic process.
He has extensively contributed in the areas of drug targeting in parasitic diseases and membrane phospholipids transbilayer dynamics, and is currently working on elucidation of actin cytoskeletal network in Leishmania.
E-cadherin binding to p120ctn may activate SRC leading to activation of Rac1 which results in phosphorylation of LIMK1 and LIMK2 to deactivate cofilin causing G-actin polymerization.
Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho.
For example, it was shown that β-actin zipcode binding protein 1 (ZBP1) - dependent dendritic mRNA transport contributes to proper dendritic branching.
The actin cytoskeleton directly determines the morphology of the spine, and actin regulators, small GTPases such as Rac, RhoA, and CDC42, rapidly modify this cytoskeleton.
Aldolase has also been implicated in many "moonlighting" or non-catalytic functions, based upon its binding affinity for multiple other proteins including F-actin, α-tubulin, light chain dynein, WASP, Band 3 anion exchanger, phospholipase D (PLD2), glucose transporter GLUT4, inositol trisphosphate, V-ATPase and ARNO (a guanine nucleotide exchange factor of ARF6).
It also inhibits cdc42 by binding to its tail and preventing its insertion into membranes; hence it cannot trigger WASPs and cannot lead to nucleation of F-actin.
mTORC2 has been shown to function as an important regulator of the cytoskeleton through its stimulation of F-actin stress fibers, paxillin, RhoA, Rac1, Cdc42, and protein kinase C α (PKCα).
Profilin is one of the most abundant actin monomer binders, but proteins such as CAP and (in mammals) thymosin β4 have some functional overlaps with profilin.
The cytoplasmic tail of PVRL1 can bind the protein afadin which is a scaffolding protein that binds actin.
The song features references to John Candy, JonBenét Ramsey, where one of the verses said "Got JonBenet Ramsey in my '98 Camry", Richard Pryor, and Steve Stout, while Eminem's line referring to the band as "five more zany-actin' maniacs in action" harks back to his original underground album Infinite.
Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity).