ALECSAT (Autologous Lymphoid Effector Cells Specific Against Tumor cells) technology is a novel method of epigenetic cancer immunotherapy being used by the company CytoVac.
Minor genetic and epigenetic changes with little or no effect on morphology or anatomy may produce large changes in the chemical phenotype.
The aberrant epigenetic landscape of the cancer cell is characterized by a global genomic hypomethylation, CpG island promoter hypermethylation of tumor suppressor genes, an altered histone code for critical genes and a global loss of monoacetylated and trimethylated histone H4.
Deletion of a portion of the 3’ end of the EpCAM gene causes epigenetic inactivation of the MSH2 gene by hypermethylating the promoter region of the MSH2 gene.
In 1998, experimental land for the Center for Biological Control was drastically limited in order to accommodate epigenetic research of non-GMO corn to patent genes for the genetic modification of organisms.
From the late 1980s, Lamb collaborated with Eva Jablonka, researching and writing on the inheritance of epigenetic variations, and in 2005 they co-authored the book Evolution in Four Dimensions, considered by some to be in the vanguard of an ongoing revolution within evolutionary biology.
The main focus of his experimental work was the epigenetic control of gene expression by DNA methylation in CHO cells.