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2 unusual facts about Cholesterol-dependent cytolysin


Cholesterol-dependent cytolysin

For example, perfringolysin O will preferentially bind to cholesterol-rich membranes composed mainly of phospholipids containing 18-carbon acyl chains.

The non-polar hydrocarbon tail of cholesterol orients itself toward the polar center of the membrane lipid bilayer, while the 3-β-OH group is oriented closer to the ester bonds formed by the fatty acid chains, and glycerol backbones closer to the membrane surface.


Acanthocyte

In liver dysfunction, apolipoprotein A-II deficient lipoprotein accumulates in plasma causing increased cholesterol in RBCs.

Adolf Otto Reinhold Windaus

He was involved in the discovery of the transformation of cholesterol through several steps to Colestipol

This leads to decreased enterohepatic recirculation of bile acids, increased synthesis of new bile acids by the liver from cholesterol, decreased liver cholesterol, increased LDL receptor expression, and decreasing LDL in blood.

Cyclodextrin

In 2009, research from the lab of Michael S. Brown and Joseph L. Goldstein, Nobel Prize winning scientists who pioneered the study of cholesterol metabolism, was published showing how cyclodextrin assists in moving cholesterol out of lysosomes in Niemann-Pick type C disease.

Dishman Pharmaceuticals and Chemicals

Veenendaal, The Netherlands: Dishman Netherlands B.V manufactures of Vitamin D2, Vitamin D3, Vitamin D analogues, cholesterol and lanolin related products.

Insig1

#INSIG1 plays an important role in the SREBP-mediated regulation of cholesterol biosynthesis: by binding to the sterol-sensing domain of SCAP (SREBP cleavage activating protein) it makes the SCAP/SREBP complex stay longer in the ER, thus prohibiting SCAP from carrying activated SREBP to the golgi complex.

Jin Meyerson

Meyerson has shown work internationally in several exhibitions and galleries including High Cholesterol Moment at Zach Feuer Gallery in New York, The Triumph of Painting at the Saatchi Gallery in London and at Galerie Emmanuel Perrotin in Paris.

Joseph Owades

Born in Manhattan and raised in the Bronx, he graduated from City College of New York (undergraduate) and Brooklyn Polytechnic Institute (Master’s and PhD in biochemistry, with a dissertation on cholesterol).

Lecithin—cholesterol acyltransferase

Lecithin—cholesterol acyltransferase (LCAT, also called phosphatidylcholine-sterol O-acyltransferase) is an enzyme that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface.

Lipid profile

However, the American Academy of Pediatrics and NHLBI now recommend that children aged 9–11 be screened once for severe cholesterol abnormalities.

Current recommendations for cholesterol testing come from the Adult Treatment Panel (ATP) III guidelines, and are based on many large clinical studies, such as the Framingham Heart Study.

Low-density lipoprotein

To compensate for the decreased cholesterol availability, synthesis of hepatic LDL receptors is increased, resulting in an increased clearance of LDL particles from the blood.

Michael Stuart Brown

Moving to the University of Texas Health Science Center in Dallas, now the UT Southwestern Medical Center, Brown and colleague Joseph L. Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream.

ML domain

Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol.

NSDHL

Mutations in the NSDHL gene are associated with CHILD syndrome which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males.

Poloxamer 407

It was reported in The Australian newspaper 18 November 2006 that this common ingredient in toothpaste and mouthwash can cause high cholesterol in mice.

Regeneron

The medicine, one in a class of drugs targeting the PCSK9 gene, reduced patients’ average LDL cholesterol levels to as little as 34 milligrams per deciliter after 12 weeks in the mid- stage study, presented today at the American College of Cardiology meeting in Chicago.

Sitosterolemia

Patients have markedly reduced whole-body cholesterol biosynthesis associated with suppressed hepatic, ileal, and mononuclear leukocyte hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA reductase), the rate-controlling enzyme in the cholesterol biosynthetic pathway.

Speculations about Mona Lisa

In January 2010, Dr Vito Franco, professor of pathological anatomy at Palermo University, published research in an article in La Stampa newspaper and at a medical conference in Florence which suggested that Mona Lisa showed clear signs of a build-up of fatty acids under the skin, caused by too much cholesterol.

STARD5

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1) and by liver X receptors (e.g., LXRA).

Sterol

At present the American Heart Association has recommended that supplemental plant sterols be taken only by those diagnosed with elevated cholesterol, and has particularly recommended that they not be taken by pregnant women or nursing mothers.

Sterol regulatory element-binding protein

In addition to S1P and S2P, the regulated release of transcriptionally active SREBP requires the cholesterol-sensing protein SREBP cleavage activating protein (Scap), which forms a complex with SREBP owing to interaction between their respective carboxy-terminal domains.

Steven Nissen

The lipoprotein enhanced the ability of HDL, or “good” cholesterol to usher fat out of the arteries and into the liver for excretion leading to the purchase of Esperion Therapeutics, the tiny company that had produced recombinant Apo-A1 Milano, by Pfizer for $1.3 billion.


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