It was named after explorer Edward John Eyre, who was the first to cross the Nullarbor by land.
The Eyre Highway passes close to the cliffs of the Bight between the Head of the Bight and Eucla.
From Port Wakefield it continues as the "Augusta Highway", and follows the coast, skirting Port Pirie to continue on to Port Augusta, where it terminates at the intersection of the Eyre Highway and Stuart Highway.
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The Eyre Highway forms part of the southern boundary of the district, and the Fraser Range is entirely contained within it.