In the short film series, Assassin's Creed: Lineage (a live-action short film set in the Assassin's Creed videogame franchise), the Duke's assassination is depicted with some liberties, with the protagonist Giovanni Auditore arriving only in time to see Lampugnani stab Sforza in the abdomen.
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The Duke's assassination is the catalyst for the action in the Da Vinci's Demons television series, where he is depicted to be in his late 40s (while Sforza was actually 32 when he was killed), played by Hugh Bonneville.
He married Violante Bentivoglio (1505–1550), a granddaughter of Galeazzo Maria Sforza, by his mistress Lucrezia Landriani.
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The complex is accessed through a 16th-century tower commissioned by Louis XII of France; to the side there is an oratory dedicated to Saint Bernard which contains a fresco of Christ standing before Pilate, once attributed to Hieronymus Bosch but today assigned to the Swiss Hans Witz (also known as Johannes Sapidus), who was court painter in Milan during the rule of Galeazzo Maria Sforza.