X-Nico

2 unusual facts about IL-2 receptor


IL-2 receptor

The alpha chain does not participate in signaling, but the beta chain is complexed with an enzyme called Janus kinase 1 (JAK1), that is capable of adding phosphate groups to molecules.

These data were recently confirmed and extended by energetics experiments using Isothermal Titration Calorimetry and Multi-Angle Light Scattering.


Dextromethorphan

sigma receptor agonist (Ki = 205 nM and 11,060 nM, respectively).


see also

Interleukin 15 receptor, alpha subunit

Two of these subunits, CD122 and CD132, are shared with the receptor for IL-2, but IL-2 receptor has an additional subunit (CD25).