Groundbreaking occurred on July 8, 2011 with a public ceremony that included Transportation Secretary Ray LaHood, Arkansas Governor Mike Beebe, and Senator Mark Pryor.
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Near the east end of its route, LA 106 passes through an interchange with Interstate 49 (I-49) between Opelousas and Alexandria in the southwest corner of Avoyelles Parish.
The four-laning of U.S. 90 was pushed in the 1990s by former State Senator Carl W. Bauer through his role as the chairman of the Governor’s Interstate 49 Task Force while also a member of the Greater Lafayette Chamber of Commerce.