West of Wellton, the highway curves towards the north to take a northeasterly course.
From the US side, Los Algodones is most easily reached via Interstate 8 and south a short distance (3.33 Km / 2.07 mi) along State Route 186/Andrade Road to the international border at Andrade, California.
Interstate 75 | Interstate 90 | Interstate 5 | Interstate 94 | Interstate 81 | Interstate 80 | Interstate 70 | Interstate 40 | Interstate 95 | Interstate 10 | Interstate 65 | Interstate 64 | Interstate 44 | Interstate 90 in Minnesota | Interstate 71 | Interstate 35 | Interstate 15 | Interstate 476 | Interstate 78 | Interstate Highway System | Interstate 85 | Interstate 74 | Interstate 294 | Interstate 20 | Interstate Commerce Commission | Interstate 87 | Interstate 55 | Interstate 471 | Interstate 287 | Interstate matches in Australian rules football |
The construction of railroads in the 1890s, the All-American Canal in the late 1940s, U.S. Route 80 in the 1920s later converted to Interstate 8 in the 1970s and the North American Free Trade Agreement (NAFTA) economic boom in the 1990s brought more people to Holtville and the Imperial Valley.
East of Yuma, the old route splits off Interstate 8 and parallels it to Gila Bend, it then heads to the north, crossing the Gila River near Gillespie Dam, and heads east through towns of Buckeye, Goodyear, and Avondale before reaching the city of Phoenix.