She was the eldest child and only daughter of John II Casimir Vasa, King of Poland and Grand Duke of Lithuania, by his wife Marie Louise Gonzaga.
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Godparents were Ferdinand III, Holy Roman Emperor (for whom Prince Karol Ferdynand Vasa stood proxy) and his recently new consort Eleonora Gonzaga (for whom the Lituanian Princess Theodora Krystyna Sapieha), and Pope Innocent X (represented by Nuncio Giovanni de Torres).
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