X-Nico

2 unusual facts about Recombinant


GSK716155

GSK716155 (Albugon) is a recombinant human glucagon-like peptide (GLP)-1-Albumin protein created using Human Genome Sciences' proprietary albumin fusion technology, which involves fusing the gene that expresses human albumin to the gene that expresses a therapeutically active protein (GLP-1)1.

Ovulation induction

Recombinant HCG (rHCG), recombinant luteinizing hormone (rLH) and urine-derived hCG (uHCG) are equally effective in achieving final follicular maturation in IVF with regards to pregnancy rates and risk of ovarian hyperstimulation syndrome.


Beta-chamigrene synthase

The recombinant enzyme from the plant Arabidopsis thaliana produces (+)-alpha-barbatene, (+)-thujopsene and (+)-beta-chamigrene.

Biological therapy for inflammatory bowel disease

--> Adalimumab (which is a humanized recombinant antibody to TNF) showed effectiveness in patients with moderate-to-severe Crohn's disease, but less than that of infliximab.

Cholera vaccine

WC-rBS (marketed as "Dukoral") is a monovalent inactivated vaccine containing killed whole cells of V. cholerae O1 plus additional recombinant cholera toxin B subunit.

Edward Tobinick

Tobinick has been issued patents for methods of perispinal administration, of certain recombinant DNA-derived (biologic) therapeutics including the TNF receptor fusion protein etanercept, for the treatment of certain neurologic disorders with widespread unmet medical need, including Alzheimer's disease; pain due to cancer metastasis to bone; severe, intractable, intervertebral disc-related pain and radiculopathy (including sciatica); and myasthenia gravis.

Enzo Paoletti

Enzo Paoletti is an Italian scientist who devised a strategy to produce recombinant DNA vaccines.

Fall armyworm

Spodoptera frugiperda cells (Sf9 and Sf21 cell lines) are commonly used in biomedical research for the purpose of recombinant protein expression using insect-specific viruses called baculoviruses.

Feline leukemia virus

Merial produces a recombinant vaccine consisting of canarypox virus carrying FeLV gag and env genes (sold as PUREVAX FeLV in the USA and Eurifel FeLV in Europe).

Genetically modified mammal

BioSteel is a trademark name for a high-strength based fiber material made of the recombinant spider silk-like protein extracted from the milk of transgenic goats, made by Nexia Biotechnologies.

Hepatitis B vaccine

It was withdrawn from the marketplace when Pablo DT Valenzuela, Research Director of Chiron Corporation succeeded in 1986 in making the antigen in yeast and invented the first recombinant vaccine.

Hubert Schoemaker

Declining a position to work as a post-doctoral researcher with Stanley Cohen, the co-developer of recombinant DNA, Schoemaker entered the world of business.

Immunotoxin

-- Really "the best"? Or just good, on a disease that's easily treated? --> These patients were treated with the recombinant immunotoxin, BL22, which targets the CD22 cell surface receptor, which is highly expressed on these leukemic cells.

Insect cell culture

There are currently more than 100 insect cell lines available for recombinant protein production with lines derived from Bombyx mori, Mamestra brassicae, Spodoptera frugiperda, Trichoplusia ni, and Drosophila melanogaster being of particular interest.

Jean Beggs

In 2003 she was awarded the Royal Society's Gabor Medal "for her contributions to the isolation and manipulation of recombinant DNA molecules in a eukaryotic organism, adding a new dimension to molecular and cellular biology".

Jean-Pierre Lecocq

Under his leadership secretory and non-secretory expression systems for the production of recombinant proteins in E. coli, Saccharomyces cerevisiae, Baculovirus and mammalian cells in cell culture were developed and recombinant virus technology was established.

Malaria vaccine

It is also based on the circumsporozoite protein, but additionally has the recombinant (Asn-Ala-Pro15Asn-Val-Asp-Pro)2-Leu-Arg(R32LR) protein covalently bound to a purified Pseudomonas aeruginosa toxin (A9).

Malcolm A. S. Moore

In collaboration with Amgen, recombinant G-CSF (Neupogen) was developed and in 1987 the first clinical studies were begun at Memorial Sloan-Kettering in cancer patients and pediatric patients with a genetic form of neutropenia.

Nesiritide

Nesiritide (Natrecor) is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium.

Recombinant DNA

;Golden rice : a recombinant variety of rice that has been engineered to express the enzymes responsible for β-carotene biosynthesis.

;Herbicide-resistant crops : commercial varieties of important agricultural crops (including soy, maize/corn, sorghum, canola, alfalfa and cotton) have been developed that incorporate a recombinant gene that results in resistance to the herbicide glyphosate (trade name Roundup), and simplifies weed control by glyphosate application.

Shantha Biotechnics

It is the first Indian company to develop, manufacture and market recombinant human healthcare products in India.

Sprifermin

Sprifermin as another name for human recombinant FGF18 and its manufacturers hope it will soon enter clinical trials for treatment of knee osteoarthritis.

Steven Nissen

The lipoprotein enhanced the ability of HDL, or “good” cholesterol to usher fat out of the arteries and into the liver for excretion leading to the purchase of Esperion Therapeutics, the tiny company that had produced recombinant Apo-A1 Milano, by Pfizer for $1.3 billion.

Timothy A Stewart

He was a pioneer in the technique of transferring recombinant genes to mice (transgenic mice) and in 1988 he and Philip Leder were granted a patent on a genetically engineered mammal.


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