She straddles the seas, uniting the continents, or hovers over the harbor to protect ships, cargo and crew as they embark on the perilous Atlantic crossing.
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Later works include the Virgin of the Rose in the church of St. Anne in Seville, showing Italian influences such as Pinturicchio and Raphael, as well as Lombard masters, and the The Virgin of the Navigators in the Alcázar of Seville.