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After graduating with a B.A. from Harvard in 1878, Sachs travelled to Europe and studied under some of the more prominent physicians of the time, such as Adolf Kussmaul (1822–1902), Friedrich Daniel von Recklinghausen (1833–1910), Friedrich Goltz (1834–1902), Rudolf Virchow (1821–1902), Karl Friedrich Otto Westphal (1833–1890), Theodor Meynert (1833–1892), Jean-Martin Charcot (1825–1893), and John Hughlings Jackson (1835–1911).
He also attended university in Berlin and Strasbourg and studied under Gustav Schwalbe, Friedrich Daniel von Recklinghausen, and Rudolf Virchow.