Simultaneously, tumor cells need to upregulate oncogenes, which promote or cause downstream activation of growth factors and cell survival signals such as Ras, Mitogen-activated protein kinase kinase, VEGF, or Akt.
protein | Protein subunit | Protein-protein interaction | Hfq protein | protein domain | Protein-protein_interaction | Protein Data Bank | kinase | RNA-binding protein | tyrosine kinase | Promyelocytic leukemia protein | G protein | Anaplastic lymphoma kinase | Wiskott–Aldrich syndrome protein | Protein G | protein dimer | Protein A | Janus kinase 1 | C-reactive protein | Bone morphogenetic protein 2 | AMP-activated protein kinase | Transmembrane protein | Tau protein | Sterol regulatory element-binding protein | SR protein | Rab escort protein | Protein structure | protein structure | Protein phosphatase 2 | protein kinase |
TRAF6 activates NF-κB transcription factor ‘Mitogen Activated Protein Kinases’ (MAPK) and ‘c-jun NH2 Terminal Kinases' (Jnk) which activates the transcription factor ‘Activating Transcription Factor 2’ (ATF2).
Mitogen-activated protein kinase 3 (MAPK3) is also known as "extracellular signal-regulated kinase 1" (ERK1).