X-Nico

unusual facts about Protease-activated receptor


Protease-activated receptor

Activation of PARs also led to an increase in tyrosine phosphorylation of ZAP-70 and SLP-76, two key proteins in T cell receptor (TCR) signalling.


Asilidae

The fly attacks its prey by stabbing it with its short, strong proboscis injecting the victim with saliva containing neurotoxic and proteolytic enzymes which very rapidly paralyze the victim and soon digest the insides; the fly then sucks the liquefied material through the proboscis.

C4b-binding protein

C4BP accelerates decay of C3-convertase and is a cofactor for serine protease factor I which cleaves C4b and C3b.

Chou’s distorted key theory for peptide drugs

According to Fisher’s lock-and-key model proposed by Hermann Emil Fischer in 1884 and Koshland’s induced fit theory by Daniel E. Koshland, Jr. in 1958, given a peptide, the prerequisite condition for it to be cleaved by HIV-protease is a good fit and binding between the substrate and the enzyme’s active site.

Cilevirus

The 286 kDa protein is a polyprotein involved in virus replication and has four conserved domains: methyltransferase, protease, helicase and an RNA dependent RNA polymerase.

DinI-like protein family

The SOS response, a set of cellular phenomena exhibited by eubacteria, is initiated by various causes that include DNA damage-induced replication arrest, and is positively regulated by the co-protease activity of RecA.

Equatorial spitting cobra

The venom of the Equatorial spitting cobra exhibited the common characteristic enzymatic activities of Asiatic spitting cobra venoms: low protease, phosphodiesterase, alkaline phosphomonoesterase and L-amino-acid oxidase activities, moderately high acetylcholinesterase and hyaluronidase activities and high Guanosine pentaphosphate

When ppGpp is either absent or high, HflB protease levels are high; this leads to lower CII (a lysogeny-promoting phage protein)

K-Casein

Chymosin (EC 3.4.23.4) is an aspartic protease that specifically hydrolyzes the peptide bond in Phe105-Met106 of κ- casein and is considered to be the most efficient protease for the cheesemaking industry.

Kallikrein 7

KLK7, a serine protease that in humans is encoded by the KLK7 gene

Protein superfamily

Chymotrypsin (1gg6), tobacco etch virus protease (1lvm), calicivirin (1wqs), west nile virus protease (1fp7), exfoliatin toxin (1exf), HtrA protease (1l1j), snake venom plasminogen activator (1bqy), chloroplast protease (4fln) and equine arteritis virus protease (1mbm).

Radioimmunoprecipitation assay buffer

Protease inhibitors such as PMSF or cocktail protease inhibitors which are commercially available (use according to the manufacturer's guide)

Ritonavir

This discovery, which has drastically reduced the adverse effects and improved the efficacy of protease inhibitors and HAART, was first communicated in an article published in the journal AIDS in 1997 by researchers at the University of Liverpool.

Scrapie

Lichens, Lobaria pulmonaria, may have potential for reducing the number of prions because some species contain proteases that show promise in breaking down the prion.

Tissue inhibitor of metalloproteinase

The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.

Torsin A

The protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta.

Trichorrhexis invaginata

The Netherton syndrome Mendelian Inheritance in Man is inherited as an autosomal recessive disorder due to mutations of both copies of the SPINK5 gene (localized to band 5q31-32), which encodes the serine protease inhibitor LEKTI (lymphoepithelial Kazal-type-related inhibitor).

Trypsin inhibitor

A study revealing that protease inhibitor from the eggs of the freshwater snail Pomacea canaliculata, interacting as a trypsin inhibitor with the protease of potential predators, was reported in 2010, the first direct evidence for this mechanism in the animal kingdom.

Trypsinogen

A further safeguard against inappropriate trypsin activation is the presence of inhibitors such as bovine pancreatic trypsin inhibitor (BPTI) and serine protease inhibitor Kazal-type 1 (SPINK1), which binds to any trypsin formed.


see also