Tyrosine kinase inhibitors such as imatinib (marketed as Gleevec) have been developed to treat chronic myeloid leukemia (CML), in which the BCR-ABL fusion gene (the product of a reciprocal translocation between chromosome 9 and chromosome 22) is present in >95% of cases and produces hyperactivated abl-driven protein signaling.
kinase | tyrosine kinase | Tyrosine | Anaplastic lymphoma kinase | tyrosine | Janus kinase 1 | AMP-activated protein kinase | protein kinase | Lyn (Src family Kinase) | Creatine kinase | Bruton's tyrosine kinase | Aurora kinase | Aurora B kinase | anaplastic lymphoma kinase | Tyrosine kinase | Tyrosine aminotransferase | Src family kinase | Protein tyrosine phosphatase | Mitogen-activated protein kinase kinase | Leukocyte receptor tyrosine kinase | Kinase | Janus kinase | Fructosamine-3-kinase | Cyclin-dependent kinase | Cell division cycle 7-related protein kinase | AXL receptor tyrosine kinase |
In addition, some ER may associate with cell membranes by attachment to caveolin-1 and form complexes with G proteins, striatin, receptor tyrosine kinases (e.g., EGFR and IGF-1), and non-receptor tyrosine kinases (e.g., Src).
A proportion of patients have a mutation involving the PDGFRA and FIP1L1 genes on the fourth chromosome, leading to a tyrosine kinase fusion protein.
The oligomerisation domain of the TEL protein (also called ETV6) becomes juxtaposed to the tyrosine kinase domain of JAK2, and as result the TEL-JAK2 displays constitutive kinase activity.
AXL receptor tyrosine kinase in biochemistry, a member of the receptor tyrosine kinase family of cell surface receptors
This pathway consists of agrin, muscle-specific tyrosine kinase (MuSK), acetylcholine receptors (AChRs) and the AChR-clustering protein rapsyn, encoded by the RAPSN gene.
Most GIST cells with wildtype (i.e. not mutated) c-kit instead have a mutation in another gene, PDGFR-α (platelet derived growth factor receptor alpha), which is a related tyrosine kinase.
This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate (HGS).
Leukocyte receptor tyrosine kinase, in biochemistry, a member of the receptor tyrosine kinase family of cell surface receptors
In specimens where the tyrosine kinase for Pyk-2 has been knocked-out, marginal zone B-cells will fail to develop while B-1 cells will still be present.
miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK).
The gene associated with this defect is also named after him: Btk, abbreviation for Bruton's tyrosine kinase.
In T-cells, two “downstream of tyrosine kinase” proteins DOK1 and DOK2 are proposed as PtdIns5P-binding proteins and effectors.
Specifically, Quizartinib selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 (FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth factor receptors (PDGFRs).