protein | Protein subunit | Chemical element | Protein-protein interaction | Hfq protein | protein domain | mercury (element) | Financial Industry Regulatory Authority | Element Lad | The Fifth Element | Regulatory compliance | Protein-protein_interaction | chemical element | Nuclear Regulatory Commission | Protein Data Bank | Federal Energy Regulatory Commission | RNA-binding protein | Binding of Isaac | Two-component regulatory system | Telecom Regulatory Authority of India | Promyelocytic leukemia protein | Mercury (element) | G protein | binding | Wiskott–Aldrich syndrome protein | Protein G | protein dimer | Protein A | National Association of Regulatory Utility Commissioners | Indian Gaming Regulatory Act |
Metabolism and homeostasis of fatty acid synthase is transcriptionally regulated by Upstream Stimulatory Factors (USF1 and USF2) and sterol regulatory element binding protein-1c (SREBP-1c) in response to feeding/insulin in living animals.
#INSIG1 plays an important role in the SREBP-mediated regulation of cholesterol biosynthesis: by binding to the sterol-sensing domain of SCAP (SREBP cleavage activating protein) it makes the SCAP/SREBP complex stay longer in the ER, thus prohibiting SCAP from carrying activated SREBP to the golgi complex.