Anti-Saccharomyces cerevisiae antibodies (ASCA), along with perinuclear antineutrophil cytoplasmic antibodies (pANCA), are among the two most useful and often discriminating markers for colitis.
Microarray-based readout of chromatin immunoprecipitation (ChIP-chip) for high-throughput binding-site determination relies on specific antibodies which may not always be available.
Bi-specific T-cell engager, or BiTE, a class of bispecific monoclonal antibodies
In 1990, Janice E. Clements and colleagues reported in the journal Science that antibodies to a protein encoded by the Borna virus genome are found in the blood of patients with behavioral disorders.
Rodney Robert Porter, biochemist, won the 1972 Nobel Prize in Physiology or Medicine for discovering the structure of antibodies, Whitley Professor of Biochemistry from 1967-85 at the University of Oxford
Rheumatoid factor, antinuclear antibodies, and non-organ specific antibodies may be present in the serum.
Also available are antibodies against a specific histone modification like H3 tri methyl K4.
ChIP-on-chip assays, which is based on the ability of commercially prepared antibodies to bind to DNA methylation-associated proteins like MeCP2.
Diagnosis is often made with detection of antibodies in the cerebrospinal fluid against a specific viral agent (such as herpes simplex virus) or by polymerase chain reaction that amplifies the RNA or DNA of the virus responsible (such as varicella zoster virus).
Antibodies for HSV-1 or HSV-2 are also more likely to be found individuals born outside of Israel, and individuals residing in Jerusalem and Southern Israel; people of Jewish origin living in Israel are less likely to possess antibodies against herpes.
Because there is a great progress in development of antibodies, fluorochromes and multicolor digital flow cytometres, it became a question of how to interpret cytometric data and how to achieve comparable results between facilities.
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Since the '90s immunophenotyping (staining cells with antibodies conjugated with fluorochromes and detection with flow cytometer) became the preferred method in diagnostics of haematological malignancies.
FITC (a fluorophore)-labeled anti-treponeme antibody and TRITC (another fluorophore)-labeled anti-human antibodies are added as secondary antibodies.
The Neonatal Fc receptor which in case of humans transfer the maternal antibody from mother through placenta to fetus, in this case is involved in transporting the IgG1 antibodies from mother animal's mammary gland into milk and then again from the ingested milk across the newborn intestine into the newborn animal's circulation.
Tests of a vaccine for SIV in monkeys found greater resistance to SIV in animals producing antibodies against this region.
Humanized antibody, a type of antibody modified to increase its similarity to human antibodies
The International Nonproprietary Names of humanized antibodies end in -zumab, as in omalizumab (see Nomenclature of monoclonal antibodies).
Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains for antibodies.
Antibody-drug conjugates, most, if not all, are immunotoxins but use whole antibodies and non-protein drugs
After an individual becomes infected, the immune system develops antibodies against that infectious agent.
Steitz's research may yield new insights into the diagnosis and treatment of autoimmune disorders such as lupus, which develop when patients make antibodies against their own DNA, snRNPs, or ribosomes.
Benach and pathology colleague Marc Golightly developed the critical laboratory test to detect the presence of antibodies to Borrelia burgdorferi, an ELISA test that became the original “gold standard” for Lyme diagnosis.
Lancelot Hogben was coauthor to two of the four which focused on molecular problems involving antibodies and blood transfusions while the remaining two pieces were epidemiological studies done in military settings – one in Italy and one in London – possibly due to Crew’s influence.
While performing molecular assays involving use of antibodies such as in the Western blot, immunohistochemistry, and ELISA, one should carefully choose antibodies that recognize linear or conformational epitopes.
The skin is from a person with systemic lupus erythematosus and shows IgG deposits at two different places: The first is a bandlike deposit along the epidermal basement membrane ("lupus band test" is positive); the second is within the nuclei of the epidermal cells (antinuclear antibodies are present).
Most had higher titres of antibodies against Fel d 4 than against Fel d 1, another prominent cat allergen.
He also received the Novartis medal in 2002 and delivered the Novartis medal lecture, entitled "Antibodies: a Paradigm for the Evolution of Molecular Recognition" on April 9, 2002 at Heriot-Watt University, Edinburgh.
The blasts react with antibodies to myeloperoxidase and antibodies to CD13, CD33, and CD34.
Anti-MCV antibodies are a member of the ACPA family, a group of the so-called antibodies to citrullinated protein/peptide antigens.
To establish that a disorder is an autoimmune disorder, Witebsky criteria requires that there be (1) a self-reactive antibody, (2) that a particular target for the antibody is identified (autoantigen) (3) that the disorder can be caused in animals and (4) that transferring antibodies from one animal to another triggers the disorder (passive transfer).
Founded in 2011 by Harvard chemist David R. Liu and Noubar Afeyan, CEO of Flagship Ventures, the company’s develops a class of proteins, under the trademark Intraphilin™, that enable the transport of large molecules such as antibodies into cells, thereby potentially enabling new classes of intracellular therapies.
He studied its toxin and its properties, and began in 1891 to develop an effective serum to treat the disease, following the demonstration, by Emil Adolf von Behring (1854–1917) and Kitasato Shibasaburō (1852–1931) that antibodies against the diphtheric toxin could be produced in animals.
The game is a vertically scrolling shooter with a "virus infiltration" theme: the player plays the role of the Waverider computer virus, and the enemies he or she encounters are Con-Human's antibodies, programmed to terminate any virus—including the player—getting inside the supercomputer's system.
Reverse phase protein array (RPPA) is a protein array designed as a micro- or nano-scaled dot-blot platform that allows measurement of protein expression levels in a large number of biological samples simultaneously in a quantitative manner when high-quality antibodies are available.
1980 - Finn, together with Cyril Clarke, John Gorman, Vincent Freda, and William Pollack were jointly awarded the 1980 Albert Lasker Award for Clinical Medical Research for pioneering work on the Rhesus blood group system, the role of anti-RhD antibodies in the causation of Rh disease, and the prevention of Rh disease with anti-D antibodies.
Antibodies to Ross River virus have been found in a wide variety of placental and marsupial mammals, and also in a few bird species.
The test is based on the presence of certain antibodies that prevent methylene blue dye from entering the cytoplasm of Toxoplasma organisms.
Single-chain variable fragments lack the constant Fc region found in complete antibody molecules, and, thus, the common binding sites (e.g., Protein G) used to purify antibodies.
The advantages of using monoclonal antibodies compared to using polyclonal antibodies includes: High homogeneity, absence of nonspecific antibodies and no batch-to-batch or lot-to-lot variability.
The test is based on the presence of specific IgM and IgG antibodies to a specific 50Kd OMP antigen, which is impregnated on nitrocellulose strips.