In order to keep the cytotoxic cells from killing cells just for presenting self-proteins, self-reactive T cells are deleted from the repertoire as a result of tolerance (also known as negative selection).
Human leukocyte antigen | antigen | Transporter associated with antigen processing | prostate-specific antigen | Human Leukocyte Antigen | human leukocyte antigen |
Immunophenotyping using MoAb to megakaryocyte restricted antigen (CD41 and CD61) may be diagnostic.
However, they may sting more than once, and can cause an allergic reaction—increasing effect associated with repeated exposure to the antigen.
Trees within the order Fagales possess particularly potent allergens, e.g. the prototypical Bet v1, the major white birch (Betula verrucosa) pollen antigen.
LFA1 (CD11a/CD18) short representation of Lymphocyte Function-associated Antigen 1, also called αLβ2 integrin
The molecule is bound to a tumour cell via the tumour antigen CD30 and to a macrophage via an Fc receptor.
Because APC cells are not antigen specific and capture also a self structures, in 1989 Charles Janeway proposed a new theory, so called the Infectious-Nonself Model.
DNA polymerase delta is an enzyme complex found in eukaryotes that is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA), the multisubunit replication factor C, and the 4 subunit polymerase complex: POLD1, POLD2, POLD3, and POLD4.
HLA-DQ4, a Human leukocyte antigen HLA-DQ serotype that recognizes the DQB1*04 gene products
That observation, called MHC restriction, led to a conundrum; namely, that the ability of a T cell to recognize foreign antigen also required that it recognize "self." With Paul M. Allen, Ph.D., the Robert L. Kroc Professor at Washington University School of Medicine, Unanue discovered that peptides from foreign antigens were bound to a group of molecules known as the major histocompatibility complex (MHC).
It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15).
Each adult dose contains 1440 ELISA units of viral antigen adsorbed on aluminium hydroxide (0.5 mg Al).
It was withdrawn from the marketplace when Pablo DT Valenzuela, Research Director of Chiron Corporation succeeded in 1986 in making the antigen in yeast and invented the first recombinant vaccine.
DQ7 is a form of 'split antigen' of the broad antigen group DQ3 which also contains DQ8 and DQ9.
HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group.
HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.
HLA-DR6 (DR6) is a broad-antigen serotype that is further split into HLA-DR13 and HLA-DR14 antigen serotypes.
Tanox, a biotech company based in Houston, Texas, proposed in 1987 that by targeting membrane-bound IgE (mIgE) on B lymphoblast and memory B cells, those cells can be lysed or down-regulated, thus achieving the inhibition of the production of antigen-specific IgE and hence a shift of immune balance toward non-IgE mechanisms.
#Non-specific immunostimulants act irrespective of antigenic specificity to augment immune response of other antigen or stimulate components of the immune system without antigenic specificity, such as adjuvants and non-specific immunostimulators.
Cause normal cells to increase expression of class I MHC molecules as well as class II MHC on antigen presenting cells—specifically through induction of antigen processing genes, including subunits of the immunoproteasome (MECL1, LMP2, LMP7), as well as TAP and ERAAP in addition possibly to the direct upregulation of MHC heavy chains and B2-microglobulin itself
Macrophage-1 antigen (or integrin αMβ2) is a complement receptor ("CR3") consisting of CD11b (integrin αM) and CD18 (integrin β2).
In humans it is the terminal carbohydrate forming the antigen of blood group A.
They and other CD1d-restricted T cells ('Type 2' NKT) recognize lipids and glycolipids presented by CD1d molecules, a member of the CD1 family of antigen presenting molecules, rather than peptide-MHC complexes.
Phosphorylation of serine and threonine residues is conserved during MHC class I and MHC class II antigen processing.
M-type phospholipase A2 receptor is a major antigen in idiopathic membranous nephropathy.
Occurrence of the Sialyl Lewis A antigen, detected with the CA19-9 antibody, is highly correlated advanced epithelial cancers, such as stage III and stage IV colorectal cancers.
CD90, formal name of Thymocyte antigen 1, a cluster of differentiation 90
De Lange obtained her Masters on "Chromatin structure of the human ß-globin gene locus" at the University of Amsterdam in 1981, and subsequently her PhD at the same institution in 1985 with Piet Borst on surface antigen genes in trypanosomes.
In 1942, Merrill Chase discovered that cells taken from the peritoneum of Guinea pigs that had been immunized against an antigen could transfer immunity when injected into Guinea pigs that had never been exposed to the antigen; this phenomenon was the discovery of cell-mediated immunity.
The test is based on the presence of specific IgM and IgG antibodies to a specific 50Kd OMP antigen, which is impregnated on nitrocellulose strips.
INn Trypanosoma congolense, in vitro analyses of the incorporated sugars after hydrolysis of the glycoprotein showed that glucosamine and mannose are utilized in the biosynthesis of the carbohydrate moiety directly whereas galactose was converted possibly to other intermediates before being incorporated into the antigen.
ELISA is a more modern variation of a protein assay that utilizes a specific antibody linked to an enzyme to detect the presence of an unknown amount of antigen (i.e. virus) in a sample.
Bone marrow tumour cells express the following antigen targets CD20 (98.3%), CD22 (88.3%), CD40 (83.3%), CD52 (77.4%), IgM (83.3%), MUC1 core protein (57.8%), and 1D10 (50%).