CDK5 is required for proper development of the brain and to be activated, CDK5 must associate with CDK5R1 or CDK5R2.
RNA-dependent RNA polymerase | kinase | tyrosine kinase | Anaplastic lymphoma kinase | Janus kinase 1 | Cyclin D1 | AMP-activated protein kinase | protein kinase | Lyn (Src family Kinase) | cyclin A | Creatine kinase | Bruton's tyrosine kinase | Aurora kinase | Aurora B kinase | anaplastic lymphoma kinase | Voltage-dependent calcium channel | Tyrosine kinase | Src family kinase | Spike-timing-dependent plasticity | Mitogen-activated protein kinase kinase | Limited dependent variable | Light-dependent reactions | Leukocyte receptor tyrosine kinase | Kinase | Janus kinase | Fructosamine-3-kinase | Dependent territory | dependent (record label) | ''dependent'' or ''response'' variable | dependent |
SMAR1 (Scaffold/Matrix attachment region-binding protein 1; also known as BANP), a tumour-suppressor MAR-binding protein that down-regulates Cyclin D1 expression by recruiting HDAC1-mSin3A co-repressor complex at Cyclin D1 promoter locus; SMAR1 is the target of prostaglandin A2 (PGA2) induced growth arrest.
A single cyclin A gene has been identified in Drosophila while Xenopus, mice and humans contain two distinct types of cyclin A: A1, the embryonic-specific form, and A2, the somatic form.
Altered expression of multiple genes is observed with miR-885-5p, including the CDK2 and MCM5 genes encoding cyclin-dependent kinase 2 and mini-chromosome maintenance protein MCM5, and also with several p53 target genes.
p14ARF inhibits mdm2, thus promoting p53, which promotes p21 activation, which then binds and inactivates certain cyclin-CDK complexes, which would otherwise promote transcription of genes that would carry the cell through the P18
p18 (protein) a member of the INK4 family of cyclin dependent kinase inhibitors.
An atypical form of RTT, characterized by infantile spasms or early onset epilepsy, can also be caused by a mutation to the gene encoding cyclin-dependent kinase-like 5 (CDKL5).
In 2001 he was awarded the Nobel Prize in Physiology or Medicine with Leland Hartwell and Sir Paul Nurse for their discoveries regarding cell cycle regulation by cyclin and cyclin-dependent kinases.