Inhibitory factors such as UNC-5 play essential roles in the formation and maintenance of synaptic components.
inhibitor | Acetylcholinesterase inhibitor | Selective serotonin reuptake inhibitor | Enzyme inhibitor | enzyme inhibitor | Metalloprotease inhibitor | Matrix metalloproteinase inhibitor | Inhibitor | Farnesyltransferase inhibitor | COX-2 inhibitor | ALK inhibitor | ACE inhibitor |
4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme MAGL, which it inhibits with an IC50 of 7900nM.
Due to the selectivity of its inhibition, apocynin can be widely used as an inhibitor of NADPH oxidase without interfering in other aspects of the immune system.
An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AAAD, or DOPA decarboxylase, DDC).
Astemizole does also act as FIASMA (functional inhibitor of acid sphingomyelinase).
The epsilon subunit is located in the stalk region of the F1 complex, and acts as an inhibitor of the ATPase catalytic core.
This sharply contrasts with the outcome for CML, for which the prognosis was dramatically improved by the development of imatinib as a specific inhibitor of the BCR-ABL protein and in particular for CML.
Before the introduction of eculizumab (INN and USAN, trade name Soliris), a monoclonal antibody that is a first-in-class terminal complement inhibitor, management options for patients with aHUS were extremely limited.
Peganum Harmala contains Harmaline, which is a strong MAO-inhibitor, and it is therefore often used as a 1st component in Ayahuasca ceremonies in order to inhibit the metabolisation of an orally-administered DMT molecule (2nd component).
Trilostane, an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome
The N-terminal region and the mature inhibitor are weakly related to other solananaceous proteins found in this family, from potato, tomato and henbane, which have been incorrectly described as metallocarboxypeptidase inhibitors.
He is also the first researcher who (in June 2010) successfully treated a patient affected by ALK+ lymphoma with an ALK inhibitor (crizotinib).
Merck has a Cathepsin K inhibitor in Phase 3 clinical trials by the name of Odanacatib for an expected indication of osteoporosis.
Cipemastat (rINN, also known as Ro 32-3555 and by the tentative trade name Trocade) is a selective inhibitor of matrix metalloproteinase-1 that has been investigated as an anti-arthritis agent.
Researchers from the Wellcome Trust Sanger Institute reported that the mutation of CUX1 reduces the inhibitory effects of a biological inhibitor, PIK3IP1 (phosphoinositide-3-kinase interacting protein 1), resulted in higher activity of the growth promoting enzyme, phosphoinositide 3-kinase (PI3K) which leads to tumor progression.
In the case of Duroia hirsuta, the chemical inhibitor is aided by the leafcutter ant Myrmelachista schumanni resident on and in the tree, and playing an active role in suppressing and destroying plant growth in the vicinity of their host by injecting and spraying formic acid.
Ivabradine is the most specific and selective If inhibitor and the only member of this family that is now marketed for pharmacological treatment of chronic stable angina in patients with normal sinus rhythm who have a contraindication or intolerance to beta-blockers.
A GABA transaminase inhibitor is an enzyme inhibitor that acts upon GABA transaminase.
Gemigliptin is a competitive, reversible DPP-4 inhibitor (IC50 = 16 nM) with excellent selectivity over other critical human proteases such as DPP-2, DPP-8, DPP-9, elastase, trypsin, urokinase and cathepsin G.
GSK2606414 is a drug which is the first selective inhibitor discovered for the enzyme protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), which is involved in various processes relating to cancer and neurodegenerative disorders.
Guadinomine B is the most potent known inhibitor of the Type III Secretion System (TTSS) of Gram-negative bacteria.
:* Activation of the signaling pathway by Delta4, Angiopoietin 2, insulin, or a combination of the three and a JAK inhibitor induces motor skill improvements in adult rat models of Parkinson's disease (6-hydroxydopamine model).
Renal tubular acidosis failure of HCO3- resorption(i.e., proximal renal tubular acidosis, or overdose of carbonic anhydrase inhibitor) or failure of H+ secretion (i.e. in distal renal tubular acidosis)
Methylthioninium chloride (INN, or methylene blue, proposed trade name Rember) is an investigational drug being developed by the University of Aberdeen and TauRx Therapeutics that has been shown in early clinical trials to be an inhibitor of Tau protein aggregation.
Azide has been used traditionally as an MPO inhibitor, but 4-aminobenzoic acid hydrazide (4-ABH) is a more specific inhibitor of MPO.
Netherton syndrome is an autosomal recessive disorder associated with mutations in the SPINK5 gene, which encodes the serine protease inhibitor lympho-epithelial Kazal-type-related inhibitor (LEKTI).
Indeed NFAT3 (NFATc4) is an inhibitor of cell motility by blocking the expression of LCN2.
Phenylethylidenehydrazine (PEH) is an inhibitor of the enzyme GABA transaminase (GABA-T).
Plasminogen activator inhibitor-1 has been shown to interact with ORM1.
Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits PTG and R6 and PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8).
Prinomastat (AG-3340) is a matrix metalloprotease (MMP) inhibitor with specific selectivity for MMPs 2, 3, 9, 13, and 14.
Polygodial has been tested as a very effective inhibitor of Candida albicans.
If the patient suffers from elevated pulse pressure, treatment may include medications that address this factor, such as an angiotensin-converting enzyme inhibitor (ACE inhibitor).
Plasminogen activator inhibitor 1 RNA-binding protein (serbp1, not to be confused with srebp1) is a protein that in humans is encoded by the SERBP1 gene.
Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.
It is a potent inhibitor of epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14.
The Netherton syndrome Mendelian Inheritance in Man is inherited as an autosomal recessive disorder due to mutations of both copies of the SPINK5 gene (localized to band 5q31-32), which encodes the serine protease inhibitor LEKTI (lymphoepithelial Kazal-type-related inhibitor).
A study revealing that protease inhibitor from the eggs of the freshwater snail Pomacea canaliculata, interacting as a trypsin inhibitor with the protease of potential predators, was reported in 2010, the first direct evidence for this mechanism in the animal kingdom.
A further safeguard against inappropriate trypsin activation is the presence of inhibitors such as bovine pancreatic trypsin inhibitor (BPTI) and serine protease inhibitor Kazal-type 1 (SPINK1), which binds to any trypsin formed.
rhynchophylla has also been shown to be a powerful MAO-B inhibitor.
Varespladib methyl (also known as A-002, formerly LY333013 and S-3013) is a secretory phospholipase A2 (sPLA2) inhibitor formerly under development by Anthera Pharmaceuticals as a treatment for acute coronary syndrome (ACS).
Members of this family also synthesize tetrodotoxin (TTX), an ancient marine alkaloid and powerful neurotoxin (Na+ pump inhibitor, 1 mg can kill an adult) that serves to protect members of an order of fishes, the Tetraodontiformes (tetras-four and odontos-tooth), which include the puffer fish (see fugu, raw puffer fish served in Japan).
Fluoxetine (Prozac), euphemistically referred to as Vitamin P, a selective serotonin reuptake inhibitor (SSRI) used for depression and various mental disorders
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Paroxetine (Paxil), euphemistically referred to as Vitamin P, a selective serotonin reuptake inhibitor (SSRI) used for depression and anxiety disorders
Volasertib (also known as BI 6727) is a small molecule inhibitor of the PLK1 (polo-like kinase 1) protein being developed by Boehringer Ingelheim for use as an anti-cancer agent.
EPRS is a component of the interferon-gamma-activated inhibitor of translation (GAIT) complex, which interacts with stem-loop elements (GAIT elements) in mRNAs encoding proinflammatory proteins, for example, vascular endothelial growth factor-A (VEGFA).
There have been several candidate markers for cancer; most notably genes coding for elafin, antileukoproteinase 1 (previously called secretory leucocyte proteinase inhibitor, SLPI), WAP four disulphide core domain protein 1 (previously called prostate stromal protein 20 kDa, PS20), and WAP four disulphide core domain protein 2 (previously called major human epididymis-specific protein E4, HE4).
ZIC2, another member of the ZIC family, has recently been found to interact with TCF7L2, enabling it to act as a Wnt/β-catenin signalling inhibitor.