X-Nico

2 unusual facts about subunit


Subunit

Monomer, a molecule that may bind chemically to other molecules to form a polymer

Protein subunit, a protein molecule that assembles with other protein molecules


Activin and inhibin

The APC/C activator protein CDH1

Cdh1 also contains a C-terminal Ile-Arg (IR) dipeptide motif at residue 565 and 566, which is suggested to bind to the Cdc27 subunit of APC.

ARPC1A

This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B.

ATP synthase gamma subunit

The human ATP synthase gamma subunit is encoded by the gene ATP5C1.

ATP5E

The epsilon subunit is located in the stalk region of the F1 complex, and acts as an inhibitor of the ATPase catalytic core.

ATP6V1F

Subunit F is a 16 kDa protein that is required for the assembly and activity of V-ATPase, and has a potential role in the differential targeting and regulation of the enzyme for specific organelles.

ATPC RNA motif

The RNA is always found within an operon encoding subunits of ATP synthase, and it is always located downstream of the gene encoding the A subunit of ATP synthase, and upstream of the C subunit gene.

BDP1

TFIIIB150 is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription.

Catharus

Comparison of mtDNA cytochrome b and NADH dehydrogenase subunit 2 as well as nuclear β-fibrinogen intron 7 sequence data indicates that this is incorrect (Winker & Pruett, 2006).

Chalinochromis

In their mtDNA NADH dehydrogenase subunit 2 sequence, Chalinochromis are closer to J. dickfeldi, J. ornatus and J. transcriptus – in particular the latter two – than to any other living fish, while J. marlieri and J. regani are closer to Telmatochromis.

Chronic myelogenous leukemia

The fused BCR-ABL protein interacts with the interleukin 3beta(c) receptor subunit.

CLCNKA

The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel.

Diving duck

mtDNA cytochrome b and NADH dehydrogenase subunit 2 sequence data indicate that the dabbling and diving ducks are fairly distant from each other, the outward similarities being due to convergent evolution.

DNA polymerase delta

DNA polymerase delta is an enzyme complex found in eukaryotes that is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA), the multisubunit replication factor C, and the 4 subunit polymerase complex: POLD1, POLD2, POLD3, and POLD4.

Electron-transferring flavoprotein

ETFs are heterodimeric proteins composed of an alpha and beta subunit (ETFA and ETFB), and contain an FAD cofactor and AMP.

Erythromelalgia

Primary erythromelalgia is caused by mutation of the voltage-gated sodium channel α-subunit gene SCN9A.

Glutamate—cysteine ligase

Glutamate cysteine ligase modifier subunit (GCLM, ~31 kDa) increases the catalytic efficiency of GCLC.

GNPTG

The GNPTG gene codes instructions for making the gamma subunit of an enzyme called GlcNAc-1-phosphotransferase (also called N-acetylglucosamine-1-phosphate transferase).

Idiopathic generalized epilepsy

Mutations in the calcium channel α subunit encoding gene CACNA1H and the GABA receptor γ subunit encoding gene GABRG2 yield susceptibility for CAE.

INHBB

Inhibins are heterodimeric glycoproteins composed of an α subunit (INHA) and one of two homologous, but distinct, β subunits (βA or βB, this protein).

Interleukin 12 subunit beta

Interleukin 12 receptor, beta 2 subunit(IL12Rβ2) is a product of the IL12-R β2 gene.

Interleukin 15 receptor, alpha subunit

Two of these subunits, CD122 and CD132, are shared with the receptor for IL-2, but IL-2 receptor has an additional subunit (CD25).

Interleukin 27 receptor, alpha subunit

Interleukin 27 receptor, alpha subunit has been shown to interact with STAT1.

Interleukin-5 receptor

In fact, the β-subunit of the IL-5 receptor is also found in IL-3 and GM-CSF receptors where it is associated with IL-3Rα and GM-CSFRα subunits respectively.

Julidochromis

In their mtDNA NADH dehydrogenase subunit 2 sequence, Chalinochromis are closer to J. dickfeldi, the Golden Julie (J. ornatus) and the Masked Julie (J. transcriptus) – in particular the latter two – than to any other living fish, while J. marlieri and the Convict Julie (J. regani) are closer to Telmatochromis.

Knob-billed Duck

Analysis of mtDNA sequences of the cytochrome b and NADH dehydrogenase subunit 2 genes, however, suggests that it is a quite basal member of the Anatidae, vindicating the earliest placement.

Lacto-rpoB RNA motif

These genes encode a subunit of RNA polymerase, and it is hypothesized that Lacto-rpoB RNA participate in the regulation of these genes.

Messenger RNA

Upon export from the nucleus the mRNA associates with ZBP1 and the 40S subunit.

MsiK RNA motif

MsiK, the protein encoded by msiK genes, is the ATPase subunit within certain ABC-type membrane transporter proteins.

Nenad Ban

His interest in large macromolecular assemblies led him for his postdoctoral work to the Department of Molecular Biophysics and Biochemistry at Yale University where he determined the atomic structure of the large ribosomal subunit by X-ray crystallography, as part of the group in the laboratory of Thomas A. Steitz.

Nesoenas

Recent cladistic analysis of mtDNA cytochrome b, cytochrome c oxidase subunit I and NADH dehydrogenase subunit 2, as well as nuclear β-fibrinogen intron 7 sequence data, combined with a distinct morphology and behaviour, suggest that the genus is valid but not monotypic.

NRF1

Nrf1, together with Nrf2, mediates the biogenomic coordination between nuclear and mitochondrial genomes by directly regulating the expression of several nuclear-encoded ETC proteins, and indirectly regulating the three mitochondrial-encoded COX subunit genes by activating mtTFA, mtTFB1, and mtTFB2.

Patagioenas

There are 17 species of Patagioenas, which can be assigned to 4 groups based on mtDNA cytochrome b, cytochrome c oxidase subunit I, and NADH dehydrogenase subunit 2, as well as the nuclear β-fibrinogen intron 7 data combined with analyses of vocalizations and morphology.

PhiKMV-like viruses

Although phiKMV phage resembles the well-studied podovirus T7 in overall genome architecture, it was the first known T7-like phage which encoded a single-subunit RNA polymerase gene downstream its DNA metabolism genes instead of in the early genomic region.

Phosphofructokinase deficiency

In this condition, a deficiency of the M subunit (PFKM) of the phosphofructokinase enzyme impairs the ability of cells such as erythrocytes and rhabdomyocytes (skeletal muscle cells) to use carbohydrates (such as glucose) for energy.

Pittasoma

Formerly placed in the family Formicariidae, they were reclassified to Conopophagidae following analysis of mtDNA cytochrome b and NADH dehydrogenase subunit 2 sequences (Rice, 2005a,b).

RN5S1@

RNA, 5S cluster 1, also known as RN5S1@, is a human gene encoding the 5S subunit of ribosomal RNA.

RPS10

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit.

Steamer duck

However, mtDNA sequence analyses of the cytochrome b and NADH dehydrogenase subunit 2 genes indicate that Tachyeres rather belongs into a distinct clade of aberrant South American dabbling ducks, which also includes the Brazilian, the Crested, and the Bronze-winged Ducks.

Svedberg

For bacterial ribosomes, ultracentrifugation yields intact ribosomes (70S) as well as separated ribosomal subunits, the large subunit (50S) and the small subunit (30S).

White-headed Woodpecker

mtDNA cytochrome b and ATP synthase subunit 6 sequence data confirms this arrangement and also suggests that the Mount Pinos birds are closer to P. a. gravirostris (Alexander & Burns, 2006).


see also