RNA interference, also called RNA inactivation, a system that regulates the activity of genes
Short RNAs are well-known to silence TEs (transposable elements) through the RNAi (RNA interference) pathway, and Piwi-associated RNAs (piRNAs) play a crucial role in transposon silencing in the germline.
RNA | 16S ribosomal RNA | RNA polymerase | RNA polymerase II | interference | RNA-dependent RNA polymerase | RNA virus | RNA interference | RNA-binding protein | non-coding RNA | Interference (communication) | Electromagnetic interference | Transfer RNA | RNA-Seq | RNA polymerase III | RNA polymerase I | messenger RNA | Interference | U2 spliceosomal RNA | small nuclear RNA | RNA splicing | Interference (Doctor Who) | 18S ribosomal RNA | Z12 small nucleolar RNA | transfer RNA | Thin-film interference | Small nucleolar RNA R43 | RNA Tie Club | Polynucleobacter-1 RNA motif | NoRC associated RNA |
Suppression of Cdh1 by RNA interference leads to an aberrant accumulation of APCCdh1 target proteins, such as cyclin A and B, the kinase AuroraB, PLK1, Skp2 and Cdc20, another APC/c co- activator.
His and Carolyn Napoli's observations of pigment gene 'cosuppression' in Petunia flowers are examples of post transcriptional gene silencing that predated the discovery of RNA interference (RNAi) and contributed to the current understanding of the commonality of RNA-mediated gene silencing in eukaryotes.
In 2006, two of Tuschl's fellow researchers, Andrew Z. Fire and Craig C. Mello, received the Nobel Prize in Physiology or Medicine for their discovery of "RNA interference – gene silencing by double-stranded RNA".