X-Nico

unusual facts about Synthesis of 2-amino-2-deoxysugars


Synthesis of 2-amino-2-deoxysugars

The azidonitration protocol developed by Lemieux and Ratcliffe is a case in point (Scheme 2).


2CBCB-NBOMe

2CBCB-NBOMe (NBOMe-TCB-2) is a compound indirectly derived from the phenethylamine series of hallucinogens, which was discovered in 2007 at Purdue University as part of the ongoing research program of the team led by David Nichols focusing on the mapping of the specific amino acid residues responsible for ligand binding to the receptor.

Adenylate kinase

Enhanced growth and elevated photosynthetic amino acid is associated with plastidial adenylate kinase deficiency in Arabidopsis thaliana.

Aromatic L-amino acid decarboxylase inhibitor

An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AAAD, or DOPA decarboxylase, DDC).

BAG2

All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions.

Beta-thalassemia

DNA contains both the instructions (genes) for stringing amino acids together into the chains we call proteins, as well as stretches of DNA which do not code for proteins (noncoding DNA), but which may play important roles in regulating the level of working genes and proteins ultimately produced (see the expression of genes and gene translation into protein).

Broad-Spectrum Chemokine Inhibitor

The key amino acids of the BSCI peptides required for activity have been identified, and the tripeptide AcNH-Trp-Val-Gln-OH was shown to itself be a BSCI in the low micromolar range.

C10H7NO3

Kynurenic acid, a product of the normal metabolism of amino acid L-tryptophan

CCL14

It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4.

Discovery and development of triptans

The amino acids Trp343 and Tyr346 both have electron rich π-systems in their aromatic structures.

Side chains of the surrounding amino acids can have an effect on the binding of the nitrogen atom, mainly three Phe can affect the methyl groups bound to the nitrogen atom (not shown in figure 2).

The binding of Phe and the triptan is caused by π stacking interactions of the indole and amino acid and an additional effect on this interaction is because of dispersive effect of amino acid leucine (Leu)(not shown in figure 2).

Enter Life

Featuring anthropomorphic amino acids and cells and a light-hearted touch, with music by Elizabeth Swados, the film has shown considerable durability, still being shown on continuous loop at the National Museum of Natural History of the Smithsonian Institution, which sponsored the original production.

Equatorial spitting cobra

The venom of the Equatorial spitting cobra exhibited the common characteristic enzymatic activities of Asiatic spitting cobra venoms: low protease, phosphodiesterase, alkaline phosphomonoesterase and L-amino-acid oxidase activities, moderately high acetylcholinesterase and hyaluronidase activities and high Erlenmeyer–Plöchl azlactone and amino-acid synthesis

The Erlenmeyer–Plöchl azlactone and amino acid synthesis, named after Friedrich Gustav Carl Emil Erlenmeyer who partly discovered the reaction, is a series of chemical reactions which transform glycine to various other amino acids via an oxazolone and an azlactone.

Gabriel Bertrand

He then went to the Pasteur Institute in Paris, where he studied organic bases and amino acids under Gabriel Bertrand.

GLN

Glutamine, the most abundant naturally occurring amino acid in the human body

Hip fracture

Homocysteine, a toxic 'natural' amino acid linked to the cause of heart disease,

Hypusine

Deoxyhypusine synthase catalyzes the cleavage of the polyamine spermidine and transfer of its 4-aminobutyl moiety to the ε-amino group of one specific lysine residue of the eIF-5A precursor to form deoxyhypusine and 1,3-diaminopropane.

IGFBP7 RNA editing

Insulin like growth factor binding protein 7 (IGFBP7) is a 282 amino acid long protein encoded by the IGFBP7 gene.

J. Heinrich Matthaei

Whilst a post-doctoral visitor in the laboratory of Marshall Warren Nirenberg at the NIH in Bethesda, Maryland, he discovered that a synthetic RNA polynucleotide, composed of a repeating uridylic acid residue, coded for a polypeptide chain encoding just one kind of amino acid, phenylalanine.

Krishna Kumar

Kumar has given proteins hyperstable folding properties by inserting fluorinated amino acids into them.

Margaret Oakley Dayhoff

The one-letter code used for amino acids was developed by her, reflecting an attempt to reduce the size of the data files used to describe amino acid sequences in an era of punch-card computing.

Frederick Sanger's determination of the first complete amino acid sequence of a protein (insulin) in 1955, led a number of researchers to sequence various proteins from different species.

Molecular-weight size marker

Like the samples of interest, the marker is also derivitized with a fluorophore (usually with 8-aminonapthalene-1,3,6-trisulfonic acid (ANTS) or 2-aminoacridone).

Monosodium glutamate

During fermentation, selected bacteria (coryneform bacteria) cultured with ammonia and carbohydrates from sugar beets, sugar cane, tapioca or molasses, excrete amino acids into the culture broth from where L-glutamate is isolated.

Motif

Structural motif, a pattern in a protein structure formed by the spatial arrangement of amino acids

Mulch

Isopropanolamine, specifically 1-Amino-2-propanol or DOW™ monoisopropanolamine, may be used as a pigment dispersant and color fastener in these mulches.

NEDD1

WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin.

Nesiritide

Nesiritide (Natrecor) is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium.

Padmanabhan Balaram

Along with Isabella Karle, a frequent collaborator, he has also pioneered the use of alpha-amino isobutyric acid to induce and retain helicity and constrain peptide conformations.

Peter Riederer

Riederer has received 14 international awards and was sitting in the editorial and advisory boards of various peer-reviewed scientific journals including Journal of Neural Transmission, Amino Acid, New Trends in Clinical Neuropharmacology, Biogenic Amines, Functional Neurology, International Journal of Neuropsychopharmacology, Neurology Psychiatry and Brain Research, Neuropsychobiologie, Parkionsonism & Related Disorders.

PGN

Peptidoglycan, a polymer consisting of sugars and amino acids that forms a bacterial cell wall

PRL-8-53

PRL-8-53 is a nootropic research chemical derived from benzoic acid and phenylmethylamine (Benzylamine) that has been shown to act as a hypermnesic drug in humans; it was first synthesized by medical chemistry professor Nikolaus Hansl at Creighton University in the 1970s as part of his work on amino ethyl meta benzoic acid esters.

PRNP

Signal sequences in the amino- and carboxy- terminal ends are removed posttranslationally, resulting in a mature length of 208.

Progerin

This mutation activates a cryptic splice site and gives rise to a form of lamin A with a deletion of 50 amino acids near the C-terminus.

ProSavin

Prosavin uses Oxford BioMedica's Lentivector delivery system to transfer three genes, aromatic amino acid dopa decarboxylase, tyrosine hydroxylase and GTP-cyclohydrolase 1, to the striatum in the brain, reprogramming transduced cells to secrete dopamine.

Protein sparing

Bodybuilding and other strength training promotes the utilization and conservation of protein's amino acids in the body.

Proteinoid

Fox later found proteinoids similar to those he had created in his laboratory in lava and cinders from Hawaiian volcanic vents and determined that the amino acids present polymerized due to the heat of escaping gases and lava.

Ramachandran plot

Glycine has only a hydrogen atom for its side chain, with a much smaller van der Waals radius than the CH3, CH2, or CH group that starts all other amino acids.

SETDB1

The SET domain is a highly conserved, approximately 150-amino acid motif implicated in the modulation of chromatin structure.

Signal peptide peptidase

A nine amino acid-long cleavage fragment is then presented on HLA-E receptors and modulates the activity of natural killer cells.

Sin Nombre virus

Interestingly, when the prototype sequence (NMH15) of SNV detected in tissues from an HPS case was compared with the sequence of the SNV isolate (NMR11; isolated in Vero E6 cells from Peromyscus maniculatus trapped in the residence of the same case), only 16 nucleotide changes were found, and none of these changes resulted in alterations in amino acid sequences of viral proteins.

SPAMfighter

The company was founded in 2003 by Henrik Sørensen and Martin Thorborg (also known for founding Jubii and Amino).

Steven Clarke

He was also an NIH fellow in the laboratory of Peter Mitchell at Glynn Research Laboratories in Bodmin, England studying mitochondrial amino acid transport.

Streptomycetaceae

The enzyme PBGD contains a 4 amino acid insertion which is present in all Streptomyces species and Kitasatospora setae, but not any other Actinobacteria.

UGG

Tryptophan, an essential amino acid in the human diet (mRNA genetic code)

Zentrum

Zentrum, a brand name for the amino acid Arginine 1200 mg.


see also